Below are links to LBD-related research abstracts. We also offer a substantial list of articles and continuing medical education (CME) resources.
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| PubMed Excellent resource for research information. |
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| Parkinson's Disease Stages from National Parkinson Foundation Hoehn and Yahr Staging of Parkinson's Disease, Unified Parkinson Disease Rating Scale (UPDRS), and Schwab and England Activities of Daily Living. |
| March 8, 2006 | Major Biomarker Candidates For Alzheimer's Disease Explored from Science Daily, Adapted from a news release issued by Case Western Reserve University. Devoted to the current research into "Biomarkers for Alzheimer's Disease." Challenges and limitations of the current knowledge of AD biomarkers are outlined. |
| March 2006 | Dual-Tracer Dopamine Transporter and Perfusion SPECT in Differential Diagnosis of Parkinsonism Using Template-Based Discriminant Analysis by Koenraad Van Laere, MD, PhD, DrSc, et. al. Dual-tracer DAT and perfusion SPECT in combination with discrimination analysis allows an automated, accurate differentiation between the most common forms of parkinsonism in a clinically relevant setting. |
| January 2006 | Comparative analysis of cognitive impairments in lewy body Dementia and Alzheimer's disease. by I.S. Preobrazhenskaya, E.A. Mkhitaryan, N.N. Yakhno Neuropsychological studies of 50 patients with Lewy body Dementia (LBD) and 50 patients with Alzheimer's disease (AD) were performed to assess the characteristics of the cognitive impairments in these diseases. In patients with Dementias of similar severities, patients with LBD showed greater impairment of executive and visuospatial functions and had more marked neurodynamic dysfunction. Patients with AD showed more profound memory disorders. |
| December 2005 | REM sleep behaviour disorder (RBD) by Ferini-Strambi L, et. al. A strong association between RBD and alpha-synucleinopathies has been recently observed, with the sleep disorder often preceding the clinical onset of the neurodegenerative disease. The idiopathic form accounts for up to 60% of the cases reported in the three largest series of RBD patients. Follow-up studies in small samples revealed that a proportion of RBD patients will eventually develop Parkinson's disease and/or a Dementia of Lewy bodies type in the years following the RBD diagnosis. |
| November 2005 | Determinants of autonomic dysfunction in idiopathic Parkinson's disease by by Korchounov A, Kessler KR, Yakhno NN, Damulin IV, Schipper HI. Conclusions: Autonomic dysfunction as an inherent feature of IPD is present already in early disease stages. According to a logistic regression model, the severity of autonomic dysfunction in IPD is primarily related to dementiaographic but not to disease-related factors. This and the differences in predictors for motor versus autonomic decline may indicate at least partly independent neurodegenerative processes. |
| October 5, 2005 | Parkinson-Plus Syndromes by Arif Dalvi, MD and Stephen M Bloomfield, MD Descriptions of Parkinsonian syndromes. |
| October 2005 | Anosmia (loss of sense of smell) is very common in the Lewy body variant of Alzheimer's disease. by Olichney JM, et. al. Olfactory abnormalities are reported in Alzheimer's disease and Parkinson's disease. Anosmia appears to be common in Dementia with Lewy bodies but not in pure Alzheimer's disease. |
| October 2005 | Disturbance of sensory filtering in Dementia with Lewy bodies by M-P Perriol, K Dujardin, et. al. The findings show that people with LBD have severe impairment in the ability to filter out irrelevant sensory or cognitive information (e.g., background noise). There was a significant difference between LBD and both Alzheimer's and Parkinson's, and may be a useful diagnostic tool. |
| September 29, 2005 | Clinical Signs of Lewy Body Dementia Consistent With Autopsy Findings by Paula Moyer. Patients with Dementia who show hallmark signs of the Lewy body subtype often have confirmatory autopsies, according to investigators who presented their findings here at the 130th annual meeting of the American Neurological Association. |
| September 7, 2005 | Animal model of Parkinson's disease reveals striking sensitivity to common environmental toxins from News-Medical.net In findings that support a relationship between agricultural chemicals and Parkinson's disease, two groups of researchers have found new evidence that loss of DJ-1, a gene known to be linked to inherited Parkinson's disease, leads to striking sensitivity to the herbicide paraquat and the insecticide rotenone. |
| September 2005 | Evidence of Oxidative Stress in the Neocortex in Incidental Lewy Body Disease by Dalfo E, Portero-Otin M, Ayala V, Martinez A, Pamplona R, Ferrer I. The findings support antioxidant therapy in the treatment of PD to reduce cortical damage associated with oxidative stress. |
| September 2005 | Neuroleptics are associated with more severe tangle pathology in Dementia with Lewy bodies by Ballard CG, Perry RH, McKeith IG, Perry EK. Although patients were not randomized and the results which are observed need to be interpreted cautiously, if substantiated, this is an important finding with major implications for the pharmacological management of DLB patients and highlights the need to determine the impact of neuroleptics upon tangle pathology in AD. |
| September 2005 | The role of levodopa in the management of Dementia with Lewy bodies. by Molloy S, McKeith IG, O'Brien JT, Burn DJ. L-dopa was generally well tolerated in DLB but produced a significant motor response in only about one third of patients. Younger DLB cases were more likely to respond to dopaminergic treatment. |
| September 2005 | DaT-SCAN SPECT in the differential diagnosis of Dementia with Lewy bodies and Alzheimer's disease by Vaamonde-Gamo J, Flores-Barragan JM, Ibanez R, Gudin M, Hernandez A. The sensitivity and specificity of the DLB criteria vary markedly. FP-CIT SPECT may be a new tool in the differential diagnosis between DLB and AD. |
| September 2005 | Modulation of memory and visuospatial processes by biperiden and rivastigmine in elderly healthy subjects. by Wezenberg E, Verkes RJ, Sabbe BG, Ruigt GS, Hulstijn W. The results implicate acetylcholine as a modulator not only of memory but also of visuospatial abilities. |
| August 2005 | The use of memantine in Dementia with Lewy bodies by Sabbagh MN, Hake AM, Ahmed S, Farlow MR. Seven of eleven participants were stable or improved with memantine while the remaining four worsened or responded adversely when exposed to the drug. No adverse effects on motor function were observed. Conclusions: Memantine can be used safely in patients with DLB, but its symptomatic effects may be variable. |
| August 2005 | Delusions and hallucinations in Dementia with Lewy bodies: worsening with memantine by Ridha BH, Josephs KA, Rossor MN. Three patients with probable Dementia with Lewy bodies (DLB) experienced worsening delusions and visual hallucinations as a result of memantine therapy. Significant resolution occurred once treatment was discontinued. Caution is required when prescribing memantine to patients with possible DLB. |
| June 20, 2005 | Computer program that enhances the diagnostic accuracy of positron emission tomography (PET) from News-Medical.net German scientists developed a computer program that enhances the diagnostic accuracy of positron emission tomography (PET) scans with Alzheimer's patients. It is able to identify various other Dementia disorders (like frontal lobe Dementia or Lewy body disease) that also show typical, but different abnormalities in the FDG-PET image. This prototype research tool is not yet designed for commercial application. |
| June 15, 2005 | First demonstration of a vaccine for Parkinson's from News-Medical.net Researchers at the University of California, San Diego (UCSD) School of Medicine working with scientists at Elan Pharmaceuticals, have reported promising results in mice of a vaccine approach to treating Parkinson's and similar diseases. |
| June 1, 2005 | The Genetic Epidementiaiology of Neurodegenerative Disease by Lars Bertram & Rudolph E. Tanzi Genetic epidementiaiology of common neurodegenerative diseases, including Alzheimer's, Parkinson disease and LBD, focusing on the similarities and differences. |
| March 2005 | REM Sleep Behavior (RBD) by Fantini ML, Ferini-Strambi L, Montplaisir J. Idiopathic REM sleep behavior disorder: toward a better nosologic definition. |
| 2005 | Autonomic Disorders in Dementia with Lewy Bodies by Preobrazhenskaia IS, Strutsenko AA The authors believe that autonomic disorders are typical for DLB and are the result of affection of the peripheral nerves, stem and spinal autonomic structures. |
| October 2004 | ApoE 4 & the Co-occurance of Alzheimer's Pathology. by Josephs KA, Tsuboi Y, Cookson N, Watt H, Dickson DW. Apolipoprotein E epsilon 4 is a determinant for Alzheimer-type pathologic features in tauopathies, synucleinopathies, and frontotemporal degeneration. |
| January 16, 2004 | Autonomic Dysfunction in Dementia with Lewy Bodies by P. Thaisetthawatkul, MD, B. F. Boeve, MD, et. al. Autonomic dysfunction is frequent in dementia with Lewy bodies and the severity is intermediate between that of multiple system atrophy and Parkinson disease. |
| 2004 | Lewy body dementia: the litmus test for neuroleptic sensitivity and extrapyramidal symptoms by Baskys A. A review of the tolerability of atypical anti-psychotics. |
| 2004 | REM Sleep Behavior Disorder in Parkinson’s Disease and Dementia with Lewy Bodies by Bradley F. Boeve, MD, Michael H. Silber, MBChB, Tanis J. Ferman, PhD REM Sleep Behavior Disorder in Parkinson’s Disease and Dementia with Lewy Bodies. |
| December 2003 | Autonomic Failure in Neurodegenerative Disorders by Kaufmann H and Biaggioni I. Autonomic failure with orthostatic and postprandial hypotension, bowel and bladder disturbances, and sexual dysfunction are frequent, disabling features in patients with the three most prevalent neurodegenerative movement disorders: Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy (MSA), and the related neurodegenerative Lewy-body disorder characterized by isolated severe autonomic failure (pure autonomic failure, PAF). |
| November 2003 | Pharmacotherapy of Dementia with Lewy Bodies by Fernandez HH, Wu CK, Ott BR. Synopsis of medications for LBD. |
| May 2003 | Autonomic Dysfunctions in Dementia with Lewy Bodies by Horimoto Y, et. al. Findings concluded that that DLB of all pathological subtypes exhibits some kind and level of autonomic symptoms. |
| January 10, 2003 | Dementia with Lewy bodies - A ‘New’ Type of Dementia With Visual Symptoms (PDF) by Richard A. Armstrong BSc, DPhil Describes the general symptoms of dementia with Lewy bodies, the visual symptoms which have been reported in the disorder, and to discuss those visual features which may help in the differential diagnosis of dementia with Lewy bodies and Alzheimer’s disease. |
| April 2001 | Pentagon Copying is More Impaired in LBD Than in Alzheimer's by Ala TA, et. al. Conclusions: For patients with MMSE scores > or = 13, an inability to accurately copy the pentagons suggests that the diagnosis is more likely DLB than AD. The results confirm the work of others on visuospatial/constructional impairment in DLB and indicate that this feature may be helpful in its diagnosis. |
| February 2000 | A Review of Clinical Diagnosis, Neuropathology And Management Options by Tanis J. Ferman, PhD. An in-depth research paper on LBD. |
| October 1999 | Alpha-synuclein in LBD and Alzheimer's Disease by Makoto Hashimoto & Eliezer Masliah Tau and Synuclein in Neuropathology. Abstract with link to article. |
